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Minipress (prazosin) can cause dizziness, headache, and drowsiness, especially after you first start the medication or after raising the dose Physicians prescribe prazosin, sold under the brand name of Minipress, to treat nightmares for post-traumatic stress disorder (PTSD). It is a well-tolerated as an off-label treatment for PTSD-associated nightmares , with a small but significant improvement in sleep and. Prazosin (minipress) is a centrally acting alpha 1 antagonist, decreasing sympathetic tone. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Lowering blood pressure may lower your risk of a stroke or heart attack. The program is designed to recognize up-and-coming industry members who are shaping the next level, industry leaders believe. Prazosin is used to treat hypertension ( high blood pressure ). 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